GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs2465120 | chr7:65620974 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs2251844 | 1 | rs2470134 | chr15:43849886 | ADAL | chr15:43622872-43646094:+ | 0.39 | 4.33 | 1.91E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2470134 | chr15:43849886 | CATSPER2 | chr15:43922774-43959900:- | 0.3 | 4.26 | 2.56E-5 | Tumor biomarkers |
| BLCA | cis | rs7112513 | 1 | rs2471884 | chr11:117010320 | PCSK7 | chr11:117075789-117102811:- | -0.43 | -5.26 | 2.41E-7 | Protein quantitative trait loci |
| BLCA | cis | rs2275426 | 1 | rs2486447 | chr1:46545724 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.12 | 2.3E-9 | Body mass index |
| BLCA | cis | rs9473555 | 1 | rs2501962 | chr6:49453636 | CENPQ | chr6:49431096-49460820:+ | 0.28 | 5.57 | 4.7E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs2501962 | chr6:49453636 | MUT | chr6:49398994-49431031:- | -0.28 | -5.52 | 6.18E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs2501963 | chr6:49454281 | CENPQ | chr6:49431096-49460820:+ | 0.28 | 5.57 | 4.7E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs2501963 | chr6:49454281 | MUT | chr6:49398994-49431031:- | -0.28 | -5.52 | 6.18E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs7112513 | 1 | rs2513093 | chr11:116806687 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -4.86 | 1.71E-6 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs2513095 | chr11:116806269 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -4.86 | 1.75E-6 | Protein quantitative trait loci |
| BLCA | cis | rs2524005 | 1 | rs2524005 | chr6:29899677 | HCG4 | chr6:29758809-29760850:- | -0.27 | -3.83 | 0.000147 | Bipolar disorder and schizophrenia |
| BLCA | cis | rs2524005 | 1 | rs2524005 | chr6:29899677 | ZFP57 | chr6:29640171-29648887:- | 0.45 | 6.41 | 4.16E-10 | Bipolar disorder and schizophrenia |
| BLCA | cis | rs2315504 | 1 | rs2524306 | chr17:39035811 | KRT12 | chr17:39017430-39023462:- | 0.2 | 3.94 | 9.76E-5 | Height |
| BLCA | cis | rs10461617 | 1 | rs252887 | chr5:56166188 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 11.61 | 6.9E-27 | Type 2 diabetes |